Mapping the Molecular Terrain of Multiple Myeloma: A Focus on Inflammation-Driven Pathways

Abstract excerpt

<title>Abstract</title> <p> While inflammation is a recognized hallmark of multiple myeloma (MM), its role as a functional orchestrator of the bone marrow niche remains poorly defined. In this study, we harmonized transcriptomic data from the GSE80608 and GSE146649 cohorts to unearth a core signature of 22 inflammation-related differentially expressed genes (IRDEGs) that underpin MM pathogenesis. Functional mapp...

Topics

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• Cancer Mechanisms and Therapy
• Chemokine receptors and signaling
• Histone Deacetylase Inhibitors Research
• Immune Cell Function and Interaction
• Multiple Myeloma Research and Treatments
• Peptidase Inhibition and Analysis
• Protein Degradation and Inhibitors
• vaccines and immunoinformatics approaches

Identifiers and source

Literature Corpus work

d21df7db-ecd9-563b-8213-b22eb6824ca9

DOI

10.21203/rs.3.rs-9355620/v1