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Spatial transcriptomics and machine learning define exhaustion-like bone marrow T-cell islands associated with myeloma progression and clinical risk

2026-07-09

Abstract excerpt

<h4>Background</h4> Multiple myeloma (MM) progression is accompanied by remodeling of the bone marrow immune microenvironment. Local interactions among malignant plasma cells, stromal cells, myeloid cells, and immune cells not only support tumor cell survival, expansion, and immune escape, but are also closely associated with disease progression, therapeutic response, and clinical prognosis. Moreover, T cell exha...

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Literature Corpus work
451cd611-93ad-504f-8ceb-872ddceb0d3f
DOI
10.64898/2026.06.30.26356926
Open publication

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Spatial transcriptomics and machine learning define exhaustion-like bone marrow T-cell islands associated with myeloma progression and clinical riskDOI 10.64898/2026.06.30.26356926
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