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Regulatory variation: an emerging vantage point for cancer biology.

Wiley interdisciplinary reviews. Systems biology and medicine - 1 Jan 2000

Li Luolan, Lorzadeh Alireza, Hirst Martin

Abstract excerpt

Transcriptional regulation involves complex and interdependent interactions of noncoding and coding regions of the genome with proteins that interact and modify them. Genetic variation/mutation in coding and noncoding regions of the genome can drive aberrant transcription and disease. In spite of accounting for nearly 98% of the genome comparatively little is known about the contribution of noncoding DNA elements...

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Biomedical Research
Epigenesis, Genetic
Gene Expression Regulation, Neoplastic
Genetic Variation
Genome-Wide Association Study

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PMID: 24254976
DOI: 10.1002/wsbm.1250

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