Article

Altered TFEB subcellular localization in nigral dopaminergic neurons of subjects with prodromal, sporadic and <i>GBA</i> -related Parkinson’s disease and Dementia with Lewy bodies

2023-07-18

Abstract excerpt

Transcription factor EB is a master regulator of genes involved in the maintenance of autophagic and lysosomal homeostasis, processes which have been implicated in the pathogenesis of GBA -related and sporadic Parkinson’s disease (PD) and dementia with Lewy bodies (DLB). TFEB activation at the lysosomal level results in its translocation from the cytosol to the nucleus. Here, we aimed at investigating whether TFE...

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Literature Corpus work: 8064bcb4-72e1-5abe-b925-3adde774e711
DOI: 10.1101/2023.07.16.549189

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Altered TFEB subcellular localization in nigral dopaminergic neurons of subjects with prodromal, sporadic and <i>GBA</i> -related Parkinson’s disease and Dementia with Lewy bodiesDOI 10.1101/2023.07.16.549189Read

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