Rare variants in genes coding for components of the terminal pathway of the complement system in preeclampsia

Abstract excerpt

<title>Abstract</title> <p>Preeclampsia is a common multifactorial disease of pregnancy. Dysregulation of the complement activation is among emerging candidates responsible for disease pathogenesis. In a targeted exomic sequencing study we identified 14 variants within nine genes coding for components of the membrane attack complex (MAC, C5b-9) that are associated with preeclampsia. We found two rare missense var...

Topics

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• Case-Control Studies
• Complement Activation
• Complement C5
• Genetic Variation
• Mutation, Missense
• Polymorphism, Single Nucleotide
• Pre-Eclampsia
• Pregnancy

Identifiers and source

Literature Corpus work

f8f3c1e0-3192-5eb1-9902-f6b8cf855975

DOI

10.21203/rs.3.rs-4121735/v1