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Article

Quantitative Alterations in Complement Alternative Pathway and Related Genetic Analysis in Severe Phenotype Preeclampsia.

Kidney360 - 30 Sept 2021

Alrahmani Layan, Gonzalez Suarez Maria L, Cousin Margot A, Moyer Ann M, Willrich Maria Alice V, White Wendy M, Wick Myra J, Tostrud Linda J, Narang Kavita, Garovic Vesna D

Abstract excerpt

Background: Preeclampsia and hemolysis, elevated liver enzymes, and low platelets (HELLP) syndrome share many clinical and biologic features with thrombotic microangiopathy syndromes caused by complement abnormalities. Our hypothesis was that similar functional and genetic alterations in the complement alternative pathway (CAP) are present in these disorders of pregnancy. Methods: We conducted quantitative...

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Identifiers

PMID: 35373096
DOI: 10.34067/KID.0000992021
PMCID: PMC8786143

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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