Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mutations in complement regulatory proteins predispose to preeclampsia: a genetic analysis of the PROMISSE cohort.

PLoS medicine - 1 Mar 2011

Salmon Jane E, Heuser Cara, Triebwasser Michael, Liszewski M Kathryn, Kavanagh David, Roumenina Lubka, Branch D Ware, Goodship Tim, Fremeaux-Bacchi Veronique, Atkinson John P

Abstract excerpt

BACKGROUND: Pregnancy in women with systemic lupus erythematosus (SLE) or antiphospholipid antibodies (APL Ab)--autoimmune conditions characterized by complement-mediated injury--is associated with increased risk of preeclampsia and miscarriage. Our previous studies in mice indicate that complement activation targeted to the placenta drives angiogenic imbalance and placental insufficiency. METHODS AND FINDINGS:...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Complement Activation
Share to Complement C3b

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Complement C4b

Share to Complement Factor H

Share to Complement Factor I

Share to Complement System Proteins

Share to Membrane Cofactor Protein

Share to Pregnancy Outcome

Source

Open in PubMed Open full text

Identifiers

PMID: 21445332
DOI: 10.1371/journal.pmed.1001013
PMCID: PMC3062534

Genes

CFI
CFH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mutations in complement regulatory proteins predispose to preeclampsia: a genetic analysis of the PROMISSE cohort.PMID 21445332Read ↗

Common variants of fetal and maternal complement genes in preeclampsia: pregnancy specific complotype.Semantic proximity Read ↗

Increased Complement Activation and Decreased ADAMTS13 Activity Are Associated with Genetic Susceptibility in Patients with Preeclampsia/HELLP Syndrome Compared to Healthy Pregnancies: An Observational Case-Controlled StudySemantic proximity Read ↗

Understanding rare genetic variants within the terminal pathway of complement system in preeclampsia.Semantic proximity Read ↗

The role of complement in normal pregnancy and preeclampsiaSemantic proximity Read ↗

Germline mutations in the alternative pathway of complement predispose to HELLP syndrome.Semantic proximity Read ↗

Quantitative Alterations in Complement Alternative Pathway and Related Genetic Analysis in Severe Phenotype Preeclampsia.Semantic proximity Read ↗

Rare variants in genes coding for components of the terminal pathway of the complement system in preeclampsiaSemantic proximity Read ↗

Pregnancy-Associated Atypical Hemolytic Uremic Syndrome: A Case Report with MCP Gene Mutation and Successful Eculizumab TreatmentSemantic proximity Read ↗

Role of Complement Component C1q in the Onset of Preeclampsia in MiceSemantic proximity Read ↗

Identification of complement factor H variants that predispose to pre-eclampsia: A genetic and functional study.Semantic proximity Read ↗

Complement factor H-point mutation promotes the development of preeclampsia-like phenotype with multiparity in mice.Semantic proximity Read ↗

Analysis of Complement C3 Gene Reveals Susceptibility to Severe PreeclampsiaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.