Article

Clinical Significance of Cytotoxic Lymphocyte Subsets and the Expression of Perforin in Cytotoxic Lymphocytes in Secondary Hemophagocytic Lymphohistiocytosis Patients

2024-12-23

Abstract excerpt

<h4>Background: </h4> Perforin is a protein expressed in cytotoxic lymphocytes, and it plays a key role in the cytolytic effect on target cells. Mutation of the perforin gene is one of the most important pathogenic steps in primary hemophagocytic lymphohistiocytosis (pHLH). The aims of this study were to investigate the expression of perforin protein on cytotoxic lymphocytes and to determine the proportions of cyt...

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Literature Corpus work: f8ec94d3-0c2e-53bb-9fa9-8a8789549655
DOI: 10.20944/preprints202412.1852.v1

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