Article
Biology and treatment of familial hemophagocytic lymphohistiocytosis: Importance of perforin in lymphocyte‐mediated cytotoxicity and triggering of apoptosis
22 Apr 2002
Abstract excerpt
Familial hemophagocytic lymphohistiocytosis (FHL) is, without treatment, an invariably fatal disease of infancy and early childhood characterized by fever, hepatosplenomegaly, pancytopenia, and a widespread accumulation of T-lymphocytes and macrophages. During recent years, the diagnosis and the survival as well as the understanding of the disease have improved dramatically. Recent studies suggest that FHL is...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.