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Article

Genotype characteristics and immunological indicator evaluation of 311 hemophagocytic lymphohistiocytosis cases in China.

Orphanet journal of rare diseases - 6 May 2020

Zhang Jia, Sun Yuan, Shi Xiaodong, Zhang Rui, Wang Yini, Xiao Juan, Cao Jing, Gao Zhuo, Wang Jingshi, Wu Lin, Wei Wei, Wang Zhao

Abstract excerpt

BACKGROUND: Primary hemophagocytic lymphohistiocytosis (pHLH) is a genetic disorder that is classically diagnosed by genetic testing. Secondary HLH (sHLH) is usually caused by infections, malignancies, or autoimmune disorders, but may display some mutations or polymorphisms. Rapid immunological assays examining natural killer (NK) cell activity, degranulation function (CD107a), and protein expression related to...

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Identifiers

PMID: 32375849
DOI: 10.1186/s13023-020-01390-z
PMCID: PMC7201972

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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