Article
LKB1-Dependent Regulation of TPI1 Creates a Divergent Metabolic Liability between Human and Mouse Lung Adenocarcinoma.
Cancer discovery - 3 Apr 2023
Stein Benjamin D, Ferrarone John R, Gardner Eric E, Chang Jae Won, Wu David, Hollstein Pablo E, Liang Roger J, Yuan Min, Chen Qiuying, Coukos John S, Sindelar Miriam, Ngo Bryan, Gross Steven S, Shaw Reuben J, Zhang Chen, Asara John M, Moellering Raymond E, Varmus Harold, Cantley Lewis C
Abstract excerpt
KRAS is the most frequently mutated oncogene in human lung adenocarcinomas (hLUAD), and activating mutations frequently co-occur with loss-of-function mutations in TP53 or STK11/LKB1. However, mutation of all three genes is rarely observed in hLUAD, even though engineered comutation is highly aggressive in mouse lung adenocarcinoma (mLUAD). Here, we provide a mechanistic explanation for this difference by...
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