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Interplay of TP53 allelic state, blast count, and complex karyotype on survival of patients with AML and MDS

28 Jul 2023

Abstract excerpt

Several clinical and genetic factors impact overall survival (OS) in myelodysplastic neoplasms (MDS) and acute myeloid leukemia (AML), including complex karyotype (CK), TP53 allelic state, and blast count. We analyzed the interplay of these factors by performing Cox regression analysis and by determining the frequency of TP53 single-hit (sh) and double-hit (dh) events and OS in MDS (n = 747) with <5% blasts, with...

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PMID: 37505914
DOI: 10.1182/bloodadvances.2023010312

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