Article

Solid Tumor Treatment via Augmentation of Bioactive C6 Ceramide Levels with Thermally Ablative Focused Ultrasound

2023-03-23

Abstract excerpt

Sparse scan partial thermal ablation (TA) with focused ultrasound (FUS) may be deployed to treat solid tumors and increase delivery of systemically administered therapeutics. Further, C6-ceramide-loaded nanoliposomes (CNLs), which rely upon the enhanced permeation and retention (EPR) effect for delivery, have shown promise for treating solid tumors and are being tested in clinical trials. Here, our objective was t...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: f8a762f0-9b53-5fdf-bf95-f7e72eea1907
DOI: 10.1101/2023.03.23.532394

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Solid Tumor Treatment via Augmentation of Bioactive C6 Ceramide Levels with Thermally Ablative Focused UltrasoundDOI 10.1101/2023.03.23.532394Read

Ultrasound-Activated Nanobubbles Induce Durable Systemic Antitumor ImmunitySemantic proximity Read

PD-L1 blockade TAM-dependently potentiates mild photothermal therapy against triple-negative breast cancer.Semantic proximity Read

Simulation-guided non-thermal low-intensity ultrasound reprograms the tumor immune microenvironment and engages systemic antitumor immunity in a syngeneic orthotopic mouse model of breast cancerSemantic proximity Read

Combining Sonodynamic Therapy with Nanocarriers: Enhancing Treatment Targeting and EfficacySemantic proximity Read

Photo-manipulated polyunsaturated fatty acid-doped liposomal hydrogel for flexible photoimmunotherapySemantic proximity Read

The resistance of breast cancer stem cells to conventional hyperthermia and their sensitivity to nanoparticle-mediated photothermal therapy.Semantic proximity Read

Multimodal PET Defines a ‘Goldilocks’ Thermal Window for Focused Ultrasound Ablation and Immunotherapy CombinationsSemantic proximity Read

A Precision Ultrasound-Localized Sonoporation-Equipment (PULSE) Enabling Intratumoral Delivery for Cancer ImmunotherapySemantic proximity Read

Tumor-targeted AIE polymeric micelles mediated immunogenic sonodynamic therapy inhibits cancer growth and metastasisSemantic proximity Read

Therapeutic ultrasound enables rapid and robust activation of ROS-responsive prodrugs in vivoSemantic proximity Read

A Pilot Study Using Nanoparticles and Laser Induced Photothermal Ablation to Treat Low Grade Canine Mast Cell Tumors: Evaluation of Efficacy and SafetySemantic proximity Read

Dually-decorated palmitate-containing lipid nanoparticles for the targeted delivery of siRNAs against HER2 and Hsp27 in HER2+ breast cancerSemantic proximity Read