Article

Dually-decorated palmitate-containing lipid nanoparticles for the targeted delivery of siRNAs against HER2 and Hsp27 in HER2+ breast cancer

2025-07-27

Abstract excerpt

<h4>ABSTRACT</h4> Ionizable lipid nanoparticles (LNPs) have enabled significant advances in oligonucleotide therapeutics, culminating in the clinical approval of an siRNA-based formulation. Unfortunately, practical use of siRNA containing LNPs is still hampered by difficulties, one of them directing LNPs toward specific cells. To improve cell-specific delivery, we have developed a new generation of palmitate-cont...

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Literature Corpus work: 605645e8-bd25-5c62-906d-a3bed8700440
DOI: 10.1101/2025.07.27.667055

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Dually-decorated palmitate-containing lipid nanoparticles for the targeted delivery of siRNAs against HER2 and Hsp27 in HER2+ breast cancerDOI 10.1101/2025.07.27.667055Read

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