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Single-cell RNA sequencing of iPSC-derived brain organoids reveals <i>Treponema pallidum</i> infection inhibiting neurodevelopment

2024-01-23

Abstract excerpt

Congenital syphilis is a vertically transmitted bacterial infection caused by Treponema pallidum , often causing multidomain neurodevelopmental disabilities. However, little is known about the pathogenesis of this disease. Brain organoids platform derived from the induced pluripotent stem cell (iPSC) is exposed to T. pallidum infection for modelling congenital neurodevelopmental impairment. Single-cell RNA seque...

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Literature Corpus work
f8914a24-f836-5677-bde6-a1e6e031dc8b
DOI
10.1101/2024.01.23.576898
Open publication

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Single-cell RNA sequencing of iPSC-derived brain organoids reveals <i>Treponema pallidum</i> infection inhibiting neurodevelopmentDOI 10.1101/2024.01.23.576898
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