Article
Microcephaly-like phenotype triggered by novel reassortant and prototypic Oropouche virus strains in brain organoids.
EBioMedicine - 1 Aug 2026
Brum Gabrielle, Grizente Vivian, Lima Monteiro Fábio Luís, Luzia de Mello Lima Guimarães Beatriz, Goto-Silva Livia, Marcos de Azevedo Delou João, Pinheiro Mourão Pedro Junior, Carlos da Silva Gomes Ismael, Barone Enzo Oliveira, Andrade Matheus Villanueva, Lima Rafael Ferreira, Mamede Izabela, Reis Clarisse, Marim Fernanda Martins, Borges Helena Lobo, Rosenblatt Michael M, Torres Laura Cazañas, Sousa Nogueira Fábio César, Domont Gilberto Barbosa, Viana Geddes Victor Emmanuel, Aguiar Renato Santana, Tanuri Amilcar, Voloch Carolina Moreira, Rehen Stevens Kastrup
Abstract excerpt
BACKGROUND: Oropouche virus (OROV) is an emerging arbovirus currently spreading across South America, with increasing reports of neurological manifestations, severe systemic disease, and congenital abnormalities. Although traditionally associated with mild febrile illness, the recent geographic expansion and surge in OROV outbreaks have prompted attention to its neurotropic potential. METHODS: We investigated the...
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