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BASP1 Promotes Apoptosis in Diabetic Nephropathy

28 Jan 2010

Abstract excerpt

Apoptosis contributes to the development of diabetic nephropathy (DN), but the mechanisms that lead to diabetes-induced cell death are not fully understood. Here, we combined a functional genomics screen for cDNAs that induce apoptosis in vitro with transcriptional profiling of renal biopsies from patients with DN. Twelve of the 138 full-length cDNAs that induced cell death in human embryonic kidney cells matched...

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PMID: 20110383
DOI: 10.1681/asn.2009020227

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