Article

Structure-Guided Design of Therapeutic Antibodies Targeting SARS-CoV-2 Omicron Variants

2026-06-24

Abstract excerpt

<title>Abstract</title> <p>The ongoing evolution of SARS-CoV-2, particularly the emergence of Omicron subvariants, compromised the effectiveness of many therapeutic antibodies. In this study, we employed a structure-guided computational design strategy to systematically optimize the COV2-2196 antibody for improved neutralization of Omicron variants. Through iterative rounds of computational design and experimenta...

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Literature Corpus work: f844ec47-bbcd-5e48-ab50-f245c930b807
DOI: 10.21203/rs.3.rs-9917568/v1

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