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Rational in silico design identifies two mutations that restore UT28K SARS-CoV-2 monoclonal antibody activity against Omicron BA.1.

Structure (London, England : 1993) - 7 Mar 2024

Ozawa Tatsuhiko, Ikeda Yoshiki, Chen Liuan, Suzuki Rigel, Hoshino Atsushi, Noguchi Akira, Kita Shunsuke, Anraku Yuki, Igarashi Emiko, Saga Yumiko, Inasaki Noriko, Taminishi Shunta, Sasaki Jiei, Kirita Yuhei, Fukuhara Hideo, Maenaka Katsumi, Hashiguchi Takao, Fukuhara Takasuke, Hirabayashi Kenichi, Tani Hideki, Kishi Hiroyuki, Niimi Hideki

Abstract excerpt

SARS-CoV-2 rapidly mutates and acquires resistance to neutralizing antibodies. We report an in-silico-designed antibody that restores the neutralizing activity of a neutralizing antibody. Our previously generated antibody, UT28K, exhibited broad neutralizing activity against mutant variants; however, its efficacy against Omicron BA.1 was compromised by the mutation. Using previously determined structural...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 38228146
DOI: 10.1016/j.str.2023.12.013

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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