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Article

Distinct genetic signals at the FGF21 locus complicate studies of FGF21's role in diet regulation using human cohort data.

Molecular metabolism - 1 Dec 2024

Ramne Stina, García-Ureña Mario, Gillum Matthew P, Ängquist Lars, Hansen Torben, Merino Jordi, Grarup Niels

Abstract excerpt

OBJECTIVES: Experimental and genetic studies suggest that fibroblast growth factor 21 (FGF21) modulates macronutrient and alcohol preferences, but evidence of such regulation in humans remains scarce. To address this gap in translation, we aimed to map the relationships between plasma FGF21 levels, FGF21 genetic variation and habitual macronutrient intake in a large human population. METHODS: We fine-mapped and...

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Identifiers

PMID: 39426521
DOI: 10.1016/j.molmet.2024.102049
PMCID: PMC11546929

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