Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Robust human genetic evidence supporting causal effects of FGF21 on reducing alcohol consuming behaviours.

BMC medicine - 23 Mar 2026

Cronjé Héléne T, Hu Sile, Gurrell Rachel, Vujkovic Marijana, Larsson Susanna C, Mason Richard, Butt Richard, Gill Dipender

Abstract excerpt

BACKGROUND: Alcohol use disorder (AUD) represents a tremendous societal burden, yet few efficacious therapies are available and widely used. Pre-clinical and human observational data support fibroblast growth factor 21 (FGF21) as a promising therapeutic target for the treatment of AUD. The objective of this study is to identify a robust genetic instrument for FGF21 agonism and leverage it to explore the effects...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alcohol Drinking
Share to Alcoholism

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Fibroblast Growth Factors

Share to Liver Cirrhosis

Share to Mutation, Missense

Share to Polymorphism, Single Nucleotide

Share to Quantitative Trait Loci

Source

Open in PubMed Open full text

Identifiers

PMID: 41872903
DOI: 10.1186/s12916-026-04807-x
PMCID: PMC13130737

Genes

FGF21

Variants

rs838131

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Robust human genetic evidence supporting causal effects of FGF21 on reducing alcohol consuming behaviours.PMID 41872903Read ↗

Robust human genetic evidence supporting causal effects of FGF21 on reducing alcohol consuming behavioursSemantic proximity Read ↗

Genome-wide association and Mendelian randomization study of fibroblast growth factor 21 reveals causal associations with hyperlipidemia and possibly NASH.Semantic proximity Read ↗

Distinct genetic signals at the FGF21 locus complicate studies of FGF21's role in diet regulation using human cohort data.Semantic proximity Read ↗

Fibroblast growth factor 21: update on genetics and molecular biology.Semantic proximity Read ↗

FGF21, a liver hormone that inhibits alcohol intake in mice, increases in human circulation after acute alcohol ingestion and sustained binge drinking at OktoberfestSemantic proximity Read ↗

Renoprotective effects of genetically proxied fibroblast growth factor 21: Mendelian randomization, proteome-wide and metabolome-wide association studySemantic proximity Read ↗

Diet pattern determines circulating FGF21 levels while distinct FGF21 variants influence diet pattern and FGF21 levelsSemantic proximity Read ↗

KLB is associated with alcohol drinking, and its gene product β-Klotho is necessary for FGF21 regulation of alcohol preference.Semantic proximity Read ↗

FGF21 Is a Sugar-Induced Hormone Associated with Sweet Intake and Preference in Humans.Semantic proximity Read ↗

Association between alcohol and urolithiasis: a mendelian randomization study.Semantic proximity Read ↗

The interaction of rs738409, obesity, and alcohol: a population-based autopsy study.Semantic proximity Read ↗

FGF21 deletion mildly exacerbates hepatic dysfunction in MASH diet and alcohol fed ratsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.