Article

A Unique Case of Rectal Cancer with Coexistence of Multiple Pathways of Carcinogenesis

2022-04-29

Abstract excerpt

<h4>Background: </h4> Colorectal cancer with a global incidence of 10% has multiple pathways implicated in its carcinogenesis. WNT signalling is the principal underlying pathway via APC gene, while defective mismatch repair genes and epigenetic changes also have proven contribution. Case presentation Here we present an unusual case of rectal adenocarcinoma in a 66 year old woman, with germline MSH6 and PMS1 mutati...

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Literature Corpus work: f803bcae-526d-5fd7-8fad-1c2a715dcbc6
DOI: 10.21203/rs.3.rs-1601021/v1

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