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Article

mRNA Vaccine Against Japanese Encephalitis Virus Genotype IV Protects Against Lethal Infection.

Viruses - 28 Jan 2026

Cox Abigail L, Nguyen Wilson, Wales-Earl Lucy, Tang Bing, Yan Kexin, Peters Jonathan, Khromykh Alexander A, Tropée Romain, McMillan Nigel A J, Suhrbier Andreas, Rawle Daniel J

Abstract excerpt

In 2022, Australia saw an unprecedented outbreak of Japanese encephalitis virus genotype IV (JEV GIV). The outbreak involved 42 human cases with 7 fatalities, as well as affecting >80 pig farms in New South Wales and Queensland. Herein, we designed, constructed, and tested two JEV GIV mRNA vaccines encoding prME, which provided protection against a lethal JEV GIV challenge in an Ifnar-/- mouse model. The vaccines...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41754514
DOI: 10.3390/v18020171
PMCID: PMC12945019

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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