Article

Evidence for a role of skull bone marrow in human chronic pain

2025-07-21

Abstract excerpt

The skull bone marrow is emerging as a critical hub for neuroimmune signaling, yet its role in chronic pain is unknown. Using integrated positron emission tomography / magnetic resonance imaging, here we show that the levels of 18 kDa translocator (TSPO), a marker of immune cell density, is elevated in the skull bone marrow of individuals with chronic pain (N=125; chronic low back pain [cLBP], N=88; knee osteoarth...

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Literature Corpus work: f7e6ef3c-39b7-5dcf-8b88-326f87ee1f38
DOI: 10.1101/2025.07.19.25331817

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