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Article

Evidence for brain glial activation in chronic pain patients.

Brain : a journal of neurology - 1 Mar 2015

Loggia Marco L, Chonde Daniel B, Akeju Oluwaseun, Arabasz Grae, Catana Ciprian, Edwards Robert R, Hill Elena, Hsu Shirley, Izquierdo-Garcia David, Ji Ru-Rong, Riley Misha, Wasan Ajay D, Zürcher Nicole R, Albrecht Daniel S, Vangel Mark G, Rosen Bruce R, Napadow Vitaly, Hooker Jacob M

Abstract excerpt

Although substantial evidence has established that microglia and astrocytes play a key role in the establishment and maintenance of persistent pain in animal models, the role of glial cells in human pain disorders remains unknown. Here, using the novel technology of integrated positron emission t...

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Source

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Identifiers

PMID: 25582579
DOI: 10.1093/brain/awu377
PMCID: PMC4339770

Genes

TSPO

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25582579-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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