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PCC1 treatment reshapes ribosomal, lysosomal and membrane-lipid transcriptional programs in therapy-induced senescent human stromal cells

2026-08-17

Abstract excerpt

Cellular senescence combines stable proliferative arrest with extensive changes in secretory, metabolic and organelle programs. Procyanidin C1 (PCC1) has dose-dependent senomorphic and senolytic activity, but the structure of its transcriptome-wide response is not well defined. We reanalyzed published RNA-sequencing counts from bleomycin-induced senescent PSC27 human stromal cells treated with 50 µM PCC1. The prim...

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Literature Corpus work
f7e2af69-edc6-5ad1-b609-6ed7b0fee6ba
DOI
10.64898/2026.08.17.745159
Open publication

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PCC1 treatment reshapes ribosomal, lysosomal and membrane-lipid transcriptional programs in therapy-induced senescent human stromal cellsDOI 10.64898/2026.08.17.745159
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