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Multi-omics analyses reveal biological and clinical insights in recurrent stage I non-small cell lung cancer

10 Feb 2025

Abstract excerpt

Post-operative recurrence rates of stage I non-small cell lung cancer (NSCLC) range from 20% to 40%. Nonetheless, the molecular mechanisms underlying recurrence hitherto remain largely elusive. Here, we generate genomic, epigenomic and transcriptomic profiles of paired tumors and adjacent tissues from 122 stage I NSCLC patients, among which 57 patients develop recurrence after surgery during follow-up. Integrated...

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PMID: 39929832
DOI: 10.1038/s41467-024-55068-2

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