Article

Trans-sodium crocetinate suppresses apoptotic and oxidative response following myoglobin-induced cytotoxicity in HEK-2 cells

2023-07-10

Abstract excerpt

<h4>Purpose: </h4> Rhabdomyolysis (RM) is a serious fatal syndrome. The RM leads to acute kidney injury (AKI) as a fatal complication. The belief is that the RM-induced AKI is triggered by myoglobin (MB). MB activates oxidative and apoptotic pathways.Trans-sodium crocetinate (TSC) isobtained from saffron and it has antioxidant andrenoprotective effects. This research was designed to assess the mechanisms of MB-ind...

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Literature Corpus work: f7db4237-8a85-5342-aa97-553a927f3a19
DOI: 10.21203/rs.3.rs-3140940/v1

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