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Article

The renoprotective effect of diosgenin on aristolochic acid I-induced renal injury in rats: impact on apoptosis, mitochondrial dynamics and autophagy

1 Jan 2020

Abstract excerpt

Aristolochic acid I (AA-I) remains a leading cause of aristolochic acid nephropathy (AAN), however few prevention and treatment strategies exist. In this work, the nephroprotective effect of diosgenin, a steroidal saponin distributed abundantly in several plants, on AA-I-induced renal injury and its underlying mechanism were investigated. Sprague-Dawley rats were intragastrically administered with 30 mg kg-1 d-1...

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Share to Drug-Induced Hepatotoxicity and Protection
Share to Nephrotoxicity and Medicinal Plants
Share to Renal Diseases and Glomerulopathies

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PMID: 32789347
DOI: 10.1039/d0fo00401d

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