Mitochondrial dysfunction is involved in aristolochic acid I-induced apoptosis in renal proximal tubular epithelial cells

Abstract excerpt

species of herbs. AA exposure is associated with kidney injury known as aristolochic acid nephropathy (AAN). Proximal tubular epithelial cell (PTEC) is the primary target of AA and rich in mitochondria. Recently, increasing evidence suggests that mitochondrial dysfunction plays a critical role in the pathogenesis of kidney disease. However, the status of mitochondrial function in PTEC after exposure to AA remains...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Drug-Induced Hepatotoxicity and Protection
• Share to Nephrotoxicity and Medicinal Plants
• Share to Trace Elements in Health