Article

The enzymatic and neurochemical outcomes of a mutation in Mexican cavefish MAO reveal teleost-specific aspects of brain monoamine homeostasis

2022-10-11

Abstract excerpt

Monoamine oxidases (MAO; MAO-A and MAO-B in mammals) are enzymes catalyzing the degradation of biogenic amines, including monoamine neurotransmitters. In humans, coding mutations in MAOs are extremely rare and deleterious. Here, we assessed the structural and biochemical consequences of a point mutation ( P106L ) in the single mao gene of the blind cavefish Astyanax mexicanus . This mutation decreased mao enzym...

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Literature Corpus work: f7cd779a-3b68-5616-a5c0-40196b5e248a
DOI: 10.1101/2022.10.10.511577

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