Article
The enzymatic and neurochemical outcomes of a mutation in Mexican cavefish MAO reveal teleost-specific aspects of brain monoamine homeostasis.
The Journal of experimental biology - 1 Jul 2023
Pierre Constance, Callebert Jacques, Launay Jean-Marie, Leclercq Julien, Rétaux Sylvie
Abstract excerpt
Monoamine oxidases (MAO; MAO-A and MAO-B in mammals) are enzymes catalyzing the degradation of biogenic amines, including monoamine neurotransmitters. In humans, coding mutations in MAOs are extremely rare and deleterious. Here, we assessed the structural and biochemical consequences of a point mutation (P106L) in the single mao gene of the blind cavefish, Astyanax mexicanus. This mutation decreased mao enzymatic...
Topics
- Animals
- Humans
- Serotonin
- Monoamine Oxidase
- Brain
- Biogenic Amines
- Mutation
- Homeostasis
- Mammals