Article

OCT4 Negatively Regulates the Transcriptional Programming of the Early Region 3 Immune Evasion Genes of Human Adenovirus

2025-04-25

Abstract excerpt

Genomes of viruses are constrained by the virions’ nanoscale, and viral nucleotide sequences without function are a luxury. Yet the double-stranded DNA genome of human adenovirus (HAdV) contains large regions without known purpose. Using TRANSFAC and ChIP-Seq analysis, we identified binding of OCT4 (octomer-binding transcription factor 4) to a noncoding region of HAdV-D37 DNA. Manipulation of OCT4 expression impac...

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Literature Corpus work: f7be2f5f-2a2a-5175-befd-2f1b03d87803
DOI: 10.1101/2025.04.23.650321

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