Article

Refractory juvenile xanthogranuloma of the mastoid bone responsive to trametinib

2024-07-16

Abstract excerpt

Juvenile xanthogranuloma (JXG) is a clonal non-Langerhans cell histiocytic disorder characterized by a variety of cutaneous and non-cutaneous manifestations, predominantly in children. The mitogen-activated protein kinase pathway (MAPK) is a key driver in many histiocytic disorders, including JXG. We report a rare presentation of JXG in the mastoid bone of a which recurred after surgery and was refractory to two l...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: f7b17da4-3666-5514-917c-cdf67dd877eb
DOI: 10.22541/au.172115425.59987552/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Refractory juvenile xanthogranuloma of the mastoid bone responsive to trametinibDOI 10.22541/au.172115425.59987552/v1Read

Recurrent CLTC::SYK fusions and CSF1R mutations in juvenile xanthogranuloma of soft tissue.Semantic proximity Read

Activating MAPK1 (ERK2) mutation in an aggressive case of disseminated juvenile xanthogranulomaSemantic proximity Read

NTRK1 Gene Fusions Are Frequent in Juvenile XanthogranulomaSemantic proximity Read

Oral Juvenile Xanthogranuloma: A Clinicopathological, Immunohistochemical and BRAF V600E Study of Five New Cases, with Literature Review.Semantic proximity Read

Treatment of Langerhans Cell Histiocytosis and Histiocytic Disorders: A Focus on MAPK Pathway Inhibitors.Semantic proximity Read

Dabrafenib as a Therapeutic Option for Chemotherapy-Refractory pediatric Juvenile Xanthogranuloma: A Case ReportSemantic proximity Read

Biological and clinical significance of somatic mutations in Langerhans cell histiocytosis and related histiocytic neoplastic disorders.Semantic proximity Read

Dasatinib induces a dramatic response in a child with refractory juvenile xanthogranuloma with a novel MRC1-PDGFRB fusionSemantic proximity Read

BRAF V600E mutation in Juvenile Xanthogranuloma family neoplasms of the central nervous system (CNS-JXG): a revised diagnostic algorithm to include pediatric Erdheim-Chester disease.Semantic proximity Read

Juvenile xanthogranuloma: retrospective analysis of 44 pediatric cases (single tertiary care center experience).Semantic proximity Read

NTRK expression is common in xanthogranuloma and is associated with the solitary variantSemantic proximity Read

Erdheim–Chester Disease: Comprehensive Review of Molecular Profiling and Therapeutic AdvancesSemantic proximity Read