Article
Recurrent CLTC::SYK fusions and CSF1R mutations in juvenile xanthogranuloma of soft tissue.
Blood - 5 Dec 2024
Kemps Paul G, Baelde Hans J, Vorderman Ruben H P, Stelloo Ellen, Swennenhuis Joost F, Szuhai Karoly, Lamers Meindert H, Kenkhuis Boyd, Al-Hussaini Maysa, Briaire-de Bruijn Inge H, Lam Suk Wai, Bovée Judith V M G, Cleven Arjen H G, Verdijk Robert M, van Noesel Carel J M, van Dijk Marijke R, Scheijde-Vermeulen Marijn A, Bruggink Annette H, van Laar Jan A M, de Vries Andrica C H, Tissing Wim J E, van den Bos Cor, von Deimling Andreas, van Wezel Tom, van Halteren Astrid G S, Hogendoorn Pancras C W
Abstract excerpt
ABSTRACT: Juvenile xanthogranuloma (JXG) is a histiocytic neoplasm that usually presents in the skin. Rarely, extracutaneous localizations occur; the genetic drivers of this clinical variant of JXG remain incompletely characterized. We present detailed clinicopathologic and molecular data of 16 children with extracutaneous JXG and 5 adults with xanthogranulomas confined to the central nervous system (CNS) or soft...
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