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Article

NTRK1 Gene Fusions Are Frequent in Juvenile Xanthogranuloma.

The American journal of surgical pathology - 16 Apr 2025

Schlögl Elisabeth, Hürner-Unterberger Helga, Simonitsch-Klupp Ingrid, Amann Gabriele, Blank-Foltin Jaqueline, Neudert Barbara, Wozelka-Oltjan Lisa, Haberler Christine, Ebetsberger-Dachs Georg, Müllauer Leonhard

Abstract excerpt

Juvenile Xanthogranuloma (JXG) is a rare form of non-Langerhans cell histiocytosis. The most common known gene mutations affect the mitogen-activated protein (MAP) kinase, phosphoinositide 3-kinase (PI3K), and Janus kinase/signal transducer and activator of transcription ( JAK / STAT ) signaling pathways. We present a case of congenital JXG in a premature newborn from a dicygotic twin pregnancy with subdermal...

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Identifiers

PMID: 40235191
DOI: 10.1097/PAS.0000000000002405
PMCID: PMC12258803

Genes

NTRK1
TPM3

Provenance

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