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NTRK expression is common in xanthogranuloma and is associated with the solitary variant

14 Aug 2023

Abstract excerpt

BACKGROUND: Previously identified mutually-exclusive driver genes in juvenile xanthogranuloma (JXG) and adult xanthogranuloma (AXG) include mutations in MAP kinase pathway genes such as MAP2K1, BRAF, ARAF, KRAS, NRAS, PIK3CD as well as fusions in BRAF and ALK, with a subset of cases with no identified driver yet. NTRK fusion has been identified in rare cases. METHODS: We identified two consecutive index cases of...

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PMID: 37580954
DOI: 10.1111/cup.14510

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