Article
TRIM7 inhibits enterovirus replication and promotes emergence of a viral variant with increased pathogenicity.
Cell - 24 Jun 2021
Fan Wenchun, Mar Katrina B, Sari Levent, Gaszek Ilona K, Cheng Qiang, Evers Bret M, Shelton John M, Wight-Carter Mary, Siegwart Daniel J, Lin Milo M, Schoggins John W
Abstract excerpt
To control viral infection, vertebrates rely on both inducible interferon responses and less well-characterized cell-intrinsic responses composed of "at the ready" antiviral effector proteins. Here, we show that E3 ubiquitin ligase TRIM7 is a cell-intrinsic antiviral effector that restricts multiple human enteroviruses by targeting viral 2BC, a membrane remodeling protein, for ubiquitination and...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.