Article

Capsid-mediated chromatin state of the AAV vector genome controls host species range

2022-10-06

Abstract excerpt

<h4>Summary</h4> Recombinant adeno-associated viral vectors (rAAVs) are among the most commonly used vehicles for in vivo based gene therapies. However, it is hard to predict which AAV capsid will provide the most robust expression in human subjects due to the observed discordance in vector-mediated transduction between species. We used a primate specific capsid, AAV-LK03, and demonstrated that the limitation of...

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Literature Corpus work: d6ab840d-089e-5288-a4de-4e18a35307b3
DOI: 10.1101/2022.10.06.511169

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