Article

Investigating the role of IgG and Fcγ receptors in intestinal inflammation

2018-01-01

Abstract excerpt

IgA is the dominant antibody isotype found at mucosal surfaces during homeostasis. However, genetic variation in Fcγ receptors (FcγRs), a family of receptors that mediate immune cell activation by IgG, influences susceptibility to inflammatory bowel disease (IBD), suggesting that IgG may be important during gut inflammation. IBD is a chronic relapsing condition with two major subtypes, Crohn’s disease (CD) and ulc...

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Literature Corpus work: f77cad52-53e6-5a60-b70c-4d641102036f
DOI: 10.17863/cam.22893

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