Article

Insulin receptor activation by proinsulin preserves synapses and vision in retinitis pigmentosa

2020-07-14

Abstract excerpt

<title>Abstract</title> <p>Background Synaptic loss, neuronal cell death, and circuit remodeling are common features of central nervous system neurodegenerative disorders. Retinitis pigmentosa, the leading cause of inherited blindness, is a group of retinal dystrophies characterized by photoreceptor cell dysfunction and death. The insulin receptor, a key controller of metabolism, also regulates neuronal survival...

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Literature Corpus work: f7281ea5-22c3-50a6-bf30-a2d2a08149a1
DOI: 10.21203/rs.3.rs-41130/v1

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