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<i>SIRT2, TFEB, CNIH3, ADRM1</i> , AND <i>TM9SF4</i> AS POTENTIAL BIOMARKERS OF RESISTANCE TO CRIZOTINIB AND POOR PROGNOSIS IN LUNG ADENOCARCINOMA: IMPLICATIONS FOR TARGETED THERAPY AND IMMUNOTHERAPY

2025-07-11

Abstract excerpt

<h4>Background</h4> Lung adenocarcinoma (LUAD) with ALK mutations benefits from targeted treatment with ALK tyrosine kinase inhibitors, such as crizotinib. This therapy has been shown to be more effective than traditional chemotherapy, with improved tolerance in patients. However, resistance to crizotinib can develop, limiting its long-term efficacy. The aim of this study is to identify deregulated genes in crizo...

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Literature Corpus work
f6ed0a37-37b5-53d0-9606-8be70c2f521d
DOI
10.1101/2025.07.10.662953
Open publication

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<i>SIRT2, TFEB, CNIH3, ADRM1</i> , AND <i>TM9SF4</i> AS POTENTIAL BIOMARKERS OF RESISTANCE TO CRIZOTINIB AND POOR PROGNOSIS IN LUNG ADENOCARCINOMA: IMPLICATIONS FOR TARGETED THERAPY AND IMMUNOTHERAPYDOI 10.1101/2025.07.10.662953
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