Article
A H3K27M-targeted vaccine in adults with diffuse midline glioma.
Nature medicine - 1 Oct 2023
Grassl Niklas, Poschke Isabel, Lindner Katharina, Bunse Lukas, Mildenberger Iris, Boschert Tamara, Jähne Kristine, Green Edward W, Hülsmeyer Ingrid, Jünger Simone, Kessler Tobias, Suwala Abigail K, Eisele Philipp, Breckwoldt Michael O, Vajkoczy Peter, Grauer Oliver M, Herrlinger Ulrich, Tonn Joerg-Christian, Denk Monika, Sahm Felix, Bendszus Martin, von Deimling Andreas, Winkler Frank, Wick Wolfgang, Platten Michael, Sahm Katharina
Abstract excerpt
Substitution of lysine 27 to methionine in histone H3 (H3K27M) defines an aggressive subtype of diffuse glioma. Previous studies have shown that a H3K27M-specific long peptide vaccine (H3K27M-vac) induces mutation-specific immune responses that control H3K27M+ tumors in major histocompatibility complex-humanized mice. Here we describe a first-in-human treatment with H3K27M-vac of eight adult patients with...
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