Article

The SMAC Mimetic AZD5582 is a Potent HIV Latency Reversing Agent

2018-05-02

Abstract excerpt

The leading strategy towards eradication of human immunodeficiency virus (HIV) infection is the depletion of viral reservoirs through reversal of viral latency, followed by clearance of persistently infected cells. To date, a latency reversing agent (LRA) that reactivates a majority of the quiescent provirus population, without significant off-target effects, has not been identified. We show here that molecules mi...

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Literature Corpus work: f6c17aa9-4d01-597c-acf5-796c94f9d636
DOI: 10.1101/312447

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