Article

A novel mouse model expressing human forms for complement receptors <i>CR1</i> and <i>CR2</i>

2019-12-23

Abstract excerpt

The complement cascade is increasingly implicated in development of a variety of diseases with strong immune contributions such as Alzheimer’s disease and Systemic Lupus Erythematosus. Mouse models have been used to determine function of central components of the complement cascade such as C1q and C3. However, species differences in their gene structures mean that mice do not adequately replicate human complement...

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Literature Corpus work: f6a84ca6-d7e8-54b1-8c82-95c2873e2d90
DOI: 10.1101/2019.12.23.887489

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