Article

A whole genomic CRISPR-Cas9 screen identifies the amino acid transporter <i>SLC43A1</i> (LAT3) as a major determinant of oxaliplatin sensitivity in colorectal cancer cells

2025-04-24

Abstract excerpt

<h4>ABSTRACT</h4> Colorectal cancer (CRC) is the second leading cause of cancer deaths in the United States, with a five-year survival rate of 65%. Oxaliplatin was the first platinum drug shown to improve CRC patient outcomes and is now a common adjuvant therapy for advanced disease, yet 90% of patients develop resistance. Oxaliplatin was developed as a third-generation derivative of cisplatin, but recent evidenc...

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Literature Corpus work: 0b5ac4b1-a71b-564e-a6a4-5dcb589fab57
DOI: 10.1101/2025.04.21.649594

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