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Mitochondrial genome copy number measured by DNA sequencing in human blood is strongly associated with metabolic traits via cell-type composition differences

2020-10-27

Abstract excerpt

Mitochondrial genome copy number (MT-CN) varies among humans and across tissues and is highly heritable, but its causes and consequences are not well understood. When measured by bulk DNA sequencing in blood, MT-CN may reflect a combination of the number of mitochondria per cell and cell type composition. Here, we studied MT-CN variation in blood-derived DNA from 19,184 Finnish individuals using a combination of g...

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Literature Corpus work: f6526d59-ec8f-51b0-8778-ea24652867e5
DOI: 10.1101/2020.10.23.20218586

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