Mitochondrial genome copy number measured by DNA sequencing in human blood is strongly associated with metabolic traits via cell-type composition differences.

doi:10.1186/s40246-021-00335-2

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Mitochondrial genome copy number measured by DNA sequencing in human blood is strongly associated with metabolic traits via cell-type composition differences.

Human genomics - 7 Jun 2021

Ganel Liron, Chen Lei, Christ Ryan, Vangipurapu Jagadish, Young Erica, Das Indraniel, Kanchi Krishna, Larson David, Regier Allison, Abel Haley, Kang Chul Joo, Scott Alexandra, Havulinna Aki, Chiang Charleston W K, Service Susan, Freimer Nelson, Palotie Aarno, Ripatti Samuli, Kuusisto Johanna, Boehnke Michael, Laakso Markku, Locke Adam, Stitziel Nathan O, Hall Ira M

Abstract excerpt

BACKGROUND: Mitochondrial genome copy number (MT-CN) varies among humans and across tissues and is highly heritable, but its causes and consequences are not well understood. When measured by bulk DNA sequencing in blood, MT-CN may reflect a combination of the number of mitochondria per cell and cell-type composition. Here, we studied MT-CN variation in blood-derived DNA from 19184 Finnish individuals using a...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Apoptosis Regulatory Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cell Lineage

Share to DNA Copy Number Variations

Share to Exome Sequencing

Share to Genome, Mitochondrial

Share to GTP-Binding Proteins

Share to Mendelian Randomization Analysis

Share to Proto-Oncogene Proteins c-myb

Source

Open in PubMed Open full text

Identifiers

PMID: 34099068
DOI: 10.1186/s40246-021-00335-2
PMCID: PMC8185936

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mitochondrial genome copy number measured by DNA sequencing in human blood is strongly associated with metabolic traits via cell-type composition differences.PMID 34099068Read ↗

Mitochondrial genome copy number measured by DNA sequencing in human blood is strongly associated with metabolic traits via cell-type composition differencesSemantic proximity Read ↗

The genetic and phenotypic correlates of mtDNA copy number in a multi-ancestry cohort.Semantic proximity Read ↗

The genetic and phenotypic correlates of mtDNA copy number in a multi-ancestry cohortSemantic proximity Read ↗

Nuclear genetic control of mtDNA copy number and heteroplasmy in humans.Semantic proximity Read ↗

Genetic analysis of mitochondrial DNA copy number and associated traits identifies loci implicated in nucleotide metabolism, platelet activation, and megakaryocyte proliferation, and reveals a causal association of mitochondrial function with mortalitySemantic proximity Read ↗

Nuclear genetic control of mtDNA copy number and heteroplasmy in humansSemantic proximity Read ↗

Genome-wide analysis of mitochondrial DNA copy number reveals loci implicated in nucleotide metabolism, platelet activation, and megakaryocyte proliferation.Semantic proximity Read ↗

GWAS and ExWAS of blood Mitochondrial DNA copy number identifies 73 loci and highlights a potential causal role in dementiaSemantic proximity Read ↗

GWAS and ExWAS of blood mitochondrial DNA copy number identifies 71 loci and highlights a potential causal role in dementia.Semantic proximity Read ↗

Deciphering the genetic and epidemiological landscape of mitochondrial DNA abundanceSemantic proximity Read ↗

Thinking outside the nucleus: Mitochondrial DNA copy number in health and disease.Semantic proximity Read ↗

An atlas of mitochondrial DNA genotype-phenotype associations in the UK Biobank.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.