Article

Newcastle disease vaccine virus I-2 fails to acquire virulence during repeated passage in vivo

2021-12-23

Abstract excerpt

<h4>Background: </h4> This study determined whether the naturally attenuated, thermotolerant Newcastle disease vaccine virus I-2 could acquire virulence after five in vivo passages through SPF chickens. <h4>Methods: </h4> Study design was to international requirements including European Pharmacopoeia, Ph. Eur., v9.0 04/2013:0450, 2013. I-2 Working Seed (WS) was compared with five-times-passaged I-2 WS (5XP WS) i...

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Literature Corpus work: f651b102-6a7e-5df9-9ef3-9d550337e6cc
DOI: 10.12688/gatesopenres.13212.3

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