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The P protein T25M substitution is involved in the quasispecies and virulence of Newcastle disease virus.

Microbiology spectrum - 3 Mar 2026

Daguia-Wenam Prince-Théodore, Lu Kejia, Zhou Xueting, Yan Chuanqi, Tong Lina, Liu Haijin, Yang Zengqi

Abstract excerpt

The non-virulent Newcastle disease virus (NDV)-Spotted Dove strain acquires enhanced virulence after serial passage in chicken embryos. In this study, the P gene T25M substitution was identified as the critical determinant of increased pathogenicity after 100 consecutive passages in specific-pathogen-free (SPF) chicken embryos. Initial characterization of the parental Spotted Dove strain confirmed a lentogenic...

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Identifiers

PMID: 41627030
DOI: 10.1128/spectrum.00639-25
PMCID: PMC12955455

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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